Question

Given below are two statements.
Statement I - Mode of action of catecholamines, peptide and polypeptide hormones is through cell membrane receptors.
Statement II - These hormones are non-steroid, water soluble and lipid insoluble hormones.
In the light of above statements, choose the correct option from below:

• A. Both statement I and statement II are correct.
• B. Both statement I and statement II are incorrect.
• C. Statement I is correct but statement II is incorrect.
• D. Statement I is incorrect but statement II is correct.

Hint:

Hormone rule: Non-steroid hormones = membrane receptors; Steroid hormones = intracellular receptors.

Answer 1

The Correct Option is A

Concept:
Hormones can be broadly classified based on their chemical nature and mode of action into steroid and non-steroid hormones.

Step 1: Analyze Statement I. Catecholamines (e.g., adrenaline), peptide and polypeptide hormones:
• Cannot cross the lipid bilayer
• Bind to receptors on the cell membrane
• Activate second messenger systems Thus, Statement I is correct.

Step 2: Analyze Statement II. These hormones are:
• Non-steroid in nature
• Water soluble
• Lipid insoluble Thus, Statement II is correct.

Step 3: Conclusion. \[ \text{Both Statement I and Statement II are correct} \]