Question

Given below are two statements: Assertion (A): Heat inactivation of vaccine is generally performed. Reason (R): It causes extensive denaturation of Protein.

• A. Both (A) and (R) are correct and (R) is the correct explanation of (A)
• B. Both (A) and (R) are correct but (R) is not the correct explanation of (A)
• C. (A) is correct but (R) is not correct
• D. (A) is not correct but (R) is correct

Hint:

Heat can denature proteins and destroy antigenic properties. Therefore, vaccine inactivation is often done by controlled chemical methods rather than simple heating.

Answer 1

The Correct Option is D

Concept:
Vaccines can be inactivated by physical or chemical methods. However, the method should preserve antigenic structure so that the immune system can recognize it.

Step 1: Check Assertion (A).
Heat inactivation is not generally preferred for vaccines because heating can damage the antigenic proteins. \[ A \text{ is incorrect} \]

Step 2: Check Reason (R).
Heat can cause extensive denaturation of proteins. Denaturation changes the structure of proteins and may destroy important antigenic sites. \[ R \text{ is correct} \]

Step 3: Final conclusion.
Since heat can denature proteins, heat inactivation is not generally performed as the preferred method for vaccine preparation. Therefore: \[ (A) \text{ is not correct but } (R) \text{ is correct} \] \[ \therefore \text{Correct Answer is (D)} \]