Step 1: Understanding genome alteration.
Genome alteration involves changes in the DNA sequence or genetic makeup of an organism.
Step 2: Analysis of given options.
Genetic engineering and gene manipulation deliberately modify genes.
Mutation causes spontaneous or induced changes in DNA.
Cloning produces genetically identical copies without changing the genome.
Step 3: Identifying the correct option.
Since cloning does not introduce any genetic change, it cannot alter the genome.
Step 4: Conclusion.
Thus, genome cannot be altered by cloning.