Step 1: Understanding genome manipulation.
Genome manipulation refers to deliberate alteration of the genetic material of a cell to introduce, remove, or modify specific genes.
Step 2: Role of recombinant DNA (r-DNA) technology.
Recombinant DNA technology allows insertion of foreign genes into a host genome using vectors such as plasmids. This enables genetic modification at the DNA level.
Step 3: Analysis of options.
(A) Cloning: Produces identical copies but does not alter genome content.
(B) Transcription: Involves synthesis of RNA from DNA, not genome modification.
(C) r-DNA technology: Correct, as it directly manipulates genetic material.
(D) Reverse transcription: Converts RNA into DNA but does not itself manipulate the genome.
Step 4: Conclusion.
Genome manipulation is achieved through recombinant DNA technology.