Step 1: Use the parallel axis theorem, $I = I_{cm} + Md^2$, to find the total moment of inertia of the system. For a solid sphere, $I_{cm} = \frac{2}{5} MR^2$.
Step 2: Calculate the total moment of inertia $I_A$ about an axis through center $A$. The distances from $A$ to the centers of spheres $B, C, D$ are $2R, 4R, 6R$ respectively.
\[ I_A = 4\left( \frac{2}{5}MR^2 \right) + M(2R)^2 + M(4R)^2 + M(6R)^2 \]
\[ I_A = 1.6MR^2 + 4MR^2 + 16MR^2 + 36MR^2 = 57.6MR^2 \]
Step 3: Calculate the total moment of inertia $I_B$ about an axis through center $B$. The distances from $B$ to centers of spheres $A, C, D$ are $2R, 2R, 4R$ respectively.
\[ I_B = 4\left( \frac{2}{5}MR^2 \right) + M(2R)^2 + M(2R)^2 + M(4R)^2 \]
\[ I_B = 1.6MR^2 + 4MR^2 + 4MR^2 + 16MR^2 = 25.6MR^2 \]
Step 4: Find the difference:
\[ I_A - I_B = 57.6MR^2 - 25.6MR^2 = 32MR^2 \]