Question

First licensed vaccine generated by reverse vaccinology is :

• A. PCV
• B. MenB
• C. GBS
• D. DPT

Hint:

"Reverse vaccinology" gets its name because it works backward from the DNA sequence rather than forward from the cultivated microbe. It was pioneered by Dr. Rino Rappuoli specifically to defeat Meningococcus B.

Answer 1

The Correct Option is B

Step 1: Concept:
The question pertains to the history of vaccine development, specifically identifying the first vaccine produced using a modern bioinformatics technique known as "reverse vaccinology."

Step 2: Step-by-step Explanation:

• Reverse Vaccinology is a methodology that starts with the genomic sequence of a pathogen to computationally predict and identify novel antigens that are likely to invoke an immune response, rather than starting with the cultivation of the pathogen itself.

• Traditional methods failed to produce an effective vaccine against Neisseria meningitidis serogroup B (which causes meningitis) because its capsular polysaccharide is virtually identical to a human neural molecule, making it poorly immunogenic and risking autoimmunity.

• In 2000, Rino Rappuoli and his team used the genome sequence of MenB to identify novel surface proteins to use as vaccine targets.

• This groundbreaking work led to the development and licensure of the MenB vaccine (trade name Bexsero), officially making it the first licensed vaccine derived via reverse vaccinology.

Step 3: Final Answer:
The MenB vaccine is the correct answer, which corresponds to option (B).