Question

Exenatide is a:

• A. Glucagon like peptide 1 (GLP1) receptor agonist
• B. Diphenyl Peptidase-4 (DPP4) inhibitors
• C. Facilitator of glucose transport across the cell
• D. Inhibitor of glucose absorption in the GIT

Answer 1

The Correct Option is B

To determine the role of exenatide, let's analyze each option based on their mechanisms in pharmacology and physiology:

1. Glucagon like peptide 1 (GLP1) receptor agonist: GLP-1 receptor agonists are a class of medications that mimic the action of the incretin hormone GLP-1. They improve blood glucose control by enhancing insulin secretion in a glucose-dependent manner, inhibiting glucagon release, delaying gastric emptying, and promoting satiety. Exenatide is indeed a GLP-1 receptor agonist.
2. Diphenyl Peptidase-4 (DPP4) inhibitors: DPP-4 inhibitors are another class of glucose-lowering agents. They work by inhibiting the enzyme dipeptidyl peptidase-4, which results in prolonged action of incretin hormones. These hormones help increase insulin release in response to meals and decrease the release of stored glucose. Exenatide is not a DPP-4 inhibitor.
3. Facilitator of glucose transport across the cell: Medications in this category, such as insulin mimetics or insulin itself, facilitate glucose uptake by tissues. This is not the mechanism of action for exenatide.
4. Inhibitor of glucose absorption in the GIT: This refers to drugs like alpha-glucosidase inhibitors, which slow down carbohydrate absorption in the intestine. Exenatide does not work this way.

Therefore, based on the mechanism of action, the correct answer is:

Glucagon like peptide 1 (GLP1) receptor agonist

The initially provided correct answer (Diphenyl Peptidase-4 (DPP4) inhibitors) appears to be a mistake. Exenatide is categorized under GLP-1 receptor agonists, which aligns with its pharmacological properties.