Question

Long-term use of thiazide diuretics in hypertension can produce all of the following EXCEPT?

• A. Hyperkalemia
• B. Hyperuricemia
• C. Hyperlipidemia
• D. Hyperglycemia

Answer 1

The Correct Option is A

To answer the question about the effects of long-term use of thiazide diuretics in hypertension, we need to understand the common side effects associated with these medications.

1. Hyperkalemia: Thiazide diuretics typically cause hypokalemia (low potassium levels), not hyperkalemia (high potassium levels). Thiazides promote potassium loss in the urine, leading to decreased serum potassium levels.

2. Hyperuricemia: Thiazide diuretics can increase uric acid levels in the blood, leading to hyperuricemia. This can be a concern, especially in patients who are predisposed to gout.

3. Hyperlipidemia: Thiazides can cause mild increases in cholesterol and triglyceride levels, contributing to hyperlipidemia.

4. Hyperglycemia: Long-term use of thiazide diuretics can lead to impaired glucose tolerance, thereby resulting in hyperglycemia (high blood sugar levels).

Considering the list of options and the mechanisms described, the effect that thiazide diuretics do not cause is hyperkalemia.

Therefore, the answer is Hyperkalemia, as it is not a side effect of thiazide diuretics. Instead, thiazides may cause the opposite effect, hypokalemia.