Step 1: Simplify the inner square root.
For large \(x\),
\[
\sqrt{x^4+1}=x^2\sqrt{1+\frac{1}{x^4}}
\]
Using
\[
\sqrt{1+t}=1+\frac{t}{2}+O(t^2),
\]
we get
\[
\sqrt{x^4+1}=x^2\left(1+\frac{1}{2x^4}+O\left(\frac{1}{x^8}\right)\right)
\]
\[
\sqrt{x^4+1}=x^2+\frac{1}{2x^2}+O\left(\frac{1}{x^6}\right)
\]
Step 2: Substitute in the main radical.
\[
x^2+\sqrt{x^4+1}
=
x^2+x^2+\frac{1}{2x^2}+O\left(\frac{1}{x^6}\right)
\]
\[
=2x^2+\frac{1}{2x^2}+O\left(\frac{1}{x^6}\right)
\]
Thus,
\[
\sqrt{x^2+\sqrt{x^4+1}}
=
\sqrt{2x^2+\frac{1}{2x^2}+O\left(\frac{1}{x^6}\right)}
\]
Step 3: Factor \(2x^2\).
\[
\sqrt{2x^2+\frac{1}{2x^2}}
=
\sqrt{2x^2\left(1+\frac{1}{4x^4}\right)}
\]
\[
=\sqrt2x\sqrt{1+\frac{1}{4x^4}}
\]
Using
\[
\sqrt{1+t}=1+\frac{t}{2}+O(t^2),
\]
\[
\sqrt{1+\frac{1}{4x^4}}
=
1+\frac{1}{8x^4}+O\left(\frac{1}{x^8}\right)
\]
Therefore,
\[
\sqrt{x^2+\sqrt{x^4+1}}
=
\sqrt2x+\frac{\sqrt2}{8x^3}+O\left(\frac{1}{x^7}\right)
\]
Step 4: Evaluate the limit.
\[
\sqrt{x^2+\sqrt{x^4+1}}-\sqrt2x
=
\frac{\sqrt2}{8x^3}+O\left(\frac{1}{x^7}\right)
\]
Multiplying by \(x^3\),
\[
x^3\left\{\sqrt{x^2+\sqrt{x^4+1}}-\sqrt2x\right\}
=
\frac{\sqrt2}{8}+O\left(\frac{1}{x^4}\right)
\]
Hence,
\[
\lim_{x\to \infty}x^3\left\{\sqrt{x^2+\sqrt{x^4+1}}-\sqrt2x\right\}
=
\frac{\sqrt2}{8}
\]
\[
=\frac{1}{4\sqrt2}
\]
Step 5: Final conclusion.
Therefore,
\[
\boxed{\frac{1}{4\sqrt2}}
\]