Question:
Enzyme-substrate complex (ES-complex) formation was explained with 'Induced-fit' hypothesis by:
Enzyme-substrate complex (ES-complex) formation was explained with 'Induced-fit' hypothesis by:
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Koshland = Koshland's Induced-Fit (like a hand in a glove).
Updated On: Jun 6, 2026
- Emil Fisher
- E. Koshland
- Michaelis
- Northrop
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The Correct Option is B
Solution and Explanation
Step 1: Concept
Enzyme kinetics and models.
Step 2: Meaning
The "Induced-fit" model describes how an enzyme changes its active site shape to fit the substrate.
Step 3: Analysis
While Emil Fisher proposed the "Lock and Key" model, D.E. Koshland proposed the "Induced-fit" hypothesis, which suggests that the active site is flexible and molds around the substrate upon binding.
Step 4: Conclusion
E. Koshland is the proponent of the Induced-fit hypothesis.
Final Answer: (B)
Enzyme kinetics and models.
Step 2: Meaning
The "Induced-fit" model describes how an enzyme changes its active site shape to fit the substrate.
Step 3: Analysis
While Emil Fisher proposed the "Lock and Key" model, D.E. Koshland proposed the "Induced-fit" hypothesis, which suggests that the active site is flexible and molds around the substrate upon binding.
Step 4: Conclusion
E. Koshland is the proponent of the Induced-fit hypothesis.
Final Answer: (B)
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