Question

Enzyme inhibition
• [A.] Irreversible inhibitor increase \(V_{\max}\)
• [B.] Inhibition can regulate metabolism
• [C.] Competitive inhibitors bind active site
• [D.] Non competitive inhibitors bind allosteric site Choose the correct answer from the options given below:

• A. B & D Only
• B. B, C & D Only
• C. A, C & D Only
• D. A, B & C Only

Hint:

Competitive inhibitor: \[ \text{Binds active site} \] Non-competitive inhibitor: \[ \text{Binds allosteric site} \]

Answer 1

The Correct Option is B

Concept: Enzyme inhibition refers to reduction in enzyme activity due to inhibitors. Main types:
• Competitive inhibition
• Non-competitive inhibition
• Irreversible inhibition

Step 1: Analyze statement A carefully. Irreversible inhibitors:
• Permanently inactivate enzyme. Thus:
• \(V_{\max}\) decreases It never increases \(V_{\max}\). Therefore statement A is incorrect.

Step 2: Analyze statement B. Enzyme inhibition helps regulate:
• Metabolic pathways
• Cellular reactions Feedback inhibition is an important example. Hence statement B is correct.

Step 3: Analyze statement C. Competitive inhibitors:
• Compete with substrate
• Bind to active site of enzyme Thus statement C is correct.

Step 4: Analyze statement D. Non-competitive inhibitors:
• Bind to allosteric site
• Alter enzyme conformation Thus statement D is correct.

Step 5: Select correct combination. Correct statements: \[ B,\ C,\ D \] Therefore: \[ \boxed{ \text{Option (2)} } \] Final Conclusion: Correct statements about enzyme inhibition are: \[ B,\ C,\ D \] Hence correct answer is: \[ \boxed{(2)\ B,\ C\ \&\ D\ Only} \]