Question:
During preformulation studies, a drug shows 6% moisture uptake at 75% RH and 0.5% moisture uptake at 40% RH. Which packaging is most suitable for long term stability
During preformulation studies, a drug shows 6% moisture uptake at 75% RH and 0.5% moisture uptake at 40% RH. Which packaging is most suitable for long term stability
Show Hint
Alu-Alu = Absolute protection. Best for moisture-loving (hygroscopic) drugs.
Updated On: May 15, 2026
- Amber glass bottle without desiccant
- Alu-Alu blister
- PVC blister pack
- HDPE container with silica gel
Show Solution
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The Correct Option is B
Solution and Explanation
Step 1: Concept
Hygroscopicity describes the tendency of a substance to absorb moisture from the atmosphere.
Step 2: Meaning
A drug showing significant moisture uptake at high relative humidity (RH) is considered hygroscopic and needs a moisture-proof barrier.
Step 3: Analysis
PVC is permeable to moisture. Glass and HDPE provide some protection but are not absolute barriers once opened. Alu-Alu (Aluminum-Aluminum) blisters provide a total barrier against moisture, oxygen, and light.
Step 4: Conclusion
For a moisture-sensitive drug, Alu-Alu packaging offers the highest level of stability. Final Answer: (B)
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