Question:

During denaturation, which level of protein structure remains unchanged?

Show Hint

Denaturation breaks hydrogen bonds and folding but not the peptide bonds of the primary structure.
Updated On: Oct 1, 2026
  • primary
  • secondary
  • tertiary
  • quaternary
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The Correct Option is A

Solution and Explanation

Step 1: Understanding the Concept
Proteins have primary (amino acid sequence), secondary (helix or sheet), tertiary (3D fold) and quaternary (subunit assembly) structure.

Step 2: Detailed Explanation
Denaturation by heat, acids or alkalis disrupts hydrogen bonds, ionic interactions and other weak forces. So secondary, tertiary and quaternary structures change or are lost.
Covalent peptide bonds are not broken, so the primary structure remains intact.

Final Answer:
The primary structure remains unchanged, option (A). \[ \boxed{\text{Primary}} \]
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