Question:
During anaerobic respiration, pyruvate undergoes decarboxylation in presence of enzyme pyruvate decarboxylase. Which of the following coenzymes and cofactors respectively are required in this reaction?
During anaerobic respiration, pyruvate undergoes decarboxylation in presence of enzyme pyruvate decarboxylase. Which of the following coenzymes and cofactors respectively are required in this reaction?
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Vitamin B$_1$ (thiamine) is essential for decarboxylation reactions.
Updated On: Feb 4, 2026
- Acetyl Co-A and Mg$^{++}$
- Acetyl Co-A and Zn$^{++}$
- Co-enzyme Q and Mg$^{++}$
- Thiamine pyrophosphate and Zn$^{++}$
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The Correct Option is D
Solution and Explanation
Step 1: Understanding anaerobic decarboxylation.
In anaerobic respiration, pyruvate is decarboxylated to acetaldehyde by the enzyme pyruvate decarboxylase.
Step 2: Required coenzyme and cofactor.
This enzyme requires thiamine pyrophosphate (TPP) as a coenzyme and Zn$^{++}$ as a cofactor for its activity.
Step 3: Conclusion.
Thus, the correct pair is Thiamine pyrophosphate and Zn$^{++$}.
In anaerobic respiration, pyruvate is decarboxylated to acetaldehyde by the enzyme pyruvate decarboxylase.
Step 2: Required coenzyme and cofactor.
This enzyme requires thiamine pyrophosphate (TPP) as a coenzyme and Zn$^{++}$ as a cofactor for its activity.
Step 3: Conclusion.
Thus, the correct pair is Thiamine pyrophosphate and Zn$^{++$}.
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