Question:
Desmethyl diazepam is an active metabolite, having an elimination half-life of more than 40 hours, of all the following drugs EXCEPT:
Desmethyl diazepam is an active metabolite, having an elimination half-life of more than 40 hours, of all the following drugs EXCEPT:
Updated On: Mar 5, 2026
- Flurazepam
- Chlordiazepoxide
- Clorazepate
- Diazepam
Show Solution
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The Correct Option is A
Solution and Explanation
To determine which drug does not have Desmethyl diazepam as an active metabolite, we need to understand the metabolic pathways of each option provided.
- Desmethyl diazepam is a common active metabolite for many benzodiazepines including Chlordiazepoxide, Clorazepate, and Diazepam. This metabolite is known for its long elimination half-life of more than 40 hours.
- Flurazepam, however, is metabolized differently. Its primary active metabolite is N-desalkylflurazepam, which is not the same as Desmethyl diazepam.
Let's go through each drug to understand their metabolite formation:
- Diazepam: Metabolized into Desmethyl diazepam (also known as Nordiazepam), Oxazepam, and Temazepam. It is confirmed to have Desmethyl diazepam as a metabolite.
- Chlordiazepoxide: Metabolized into Nordiazepam (Desmethyl diazepam) and other metabolites. It also forms Desmethyl diazepam.
- Clorazepate: It is essentially an inactive prodrug that is rapidly decarboxylated to form Desmethyl diazepam. Thus, it directly contributes to Desmethyl diazepam formation.
- Flurazepam: Primarily metabolized to N-desalkylflurazepam, rather than Desmethyl diazepam.
Thus, the drug that does not use Desmethyl diazepam as an active metabolite is Flurazepam.
Conclusion: The correct answer is
Flurazepam
, because it is metabolized differently compared to the other options.
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