Question

Coomb's test is used for detection of:

• A. Yellow fever
• B. Syphilis
• C. Typhoid
• D. Antiglobulin

Answer 1

The Correct Option is D

The correct option is (D): Antiglobulin.

Answer 2

The question asks what the Coomb's test is used to detect. Let's check each of the given options.

1. Yellow fever: This viral disease is diagnosed using serological tests for viral antibodies or antigens, or PCR, not the Coomb's test.
2. Syphilis: Syphilis is diagnosed using tests like VDRL, RPR, or treponemal-specific antibody tests, not the Coomb's test.
3. Typhoid: Typhoid is diagnosed using the Widal test, blood culture, or stool culture, not the Coomb's test.
4. Antiglobulin: The Coomb's test, also called the antiglobulin test, uses anti-human globulin reagent to detect antibodies (immunoglobulins or complement) bound to the surface of red blood cells. It comes in a direct form, which detects antibodies already on the cells, and an indirect form, which detects antibodies in the serum. This matches exactly what the test name itself describes.

The Coomb's test is, by definition, an antiglobulin test, and none of the other listed diseases are diagnosed using it.

Therefore, the correct answer is Antiglobulin.