Question:
"Wheal and Flare" reaction is characteristic reaction associated with identification of:
"Wheal and Flare" reaction is characteristic reaction associated with identification of:
Updated On: Feb 24, 2026
- Type-1 hypersensitivity reaction
- Type-2 hypersensitivity reaction
- Type-3 hypersensitivity reaction
- Type-4 hypersensitivity reaction
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The Correct Option is A
Solution and Explanation
The question is about identifying the hypersensitivity reaction associated with the "wheal and flare" response. Let's explore each option to determine the correct match:
Understanding Hypersensitivity Reactions
-
Type-1 Hypersensitivity Reaction
- This reaction is also known as an immediate hypersensitivity reaction.
- It is mediated by IgE antibodies.
- The classic example of a Type-1 hypersensitivity reaction is an allergic reaction, such as hay fever, asthma, or anaphylaxis.
- The response includes a rapid onset of symptoms, typically within minutes of exposure to the antigen.
- Characteristic Features: The key feature here is the "wheal and flare" reaction, which is a skin response that includes edema (wheal) and redness (flare).
-
Type-2 Hypersensitivity Reaction
- This involves IgG or IgM antibodies targeting antigens on cell surfaces or the extracellular matrix.
- Examples include hemolytic anemia and Goodpasture's syndrome.
- It does not exhibit a wheal and flare reaction, rather it causes cell destruction, inflammation, or altering cellular function.
-
Type-3 Hypersensitivity Reaction
- This involves immune complex-mediated reactions.
- Diseases like systemic lupus erythematosus (SLE) and rheumatoid arthritis are examples of Type-3 reactions.
- This reaction typically presents with systemic inflammation rather than local wheal and flare.
-
Type-4 Hypersensitivity Reaction
- This is a delayed-type reaction mediated by T-cells rather than antibodies.
- Examples include contact dermatitis and the Mantoux test for tuberculosis.
- This reaction does not involve a wheal and flare response.
Conclusion
The "wheal and flare" reaction is specifically associated with a Type-1 hypersensitivity reaction. The appearance of a wheal, which is a raised area, and a flare, which is redness around it, is due to the vasodilation and increased vascular permeability caused by histamine release from mast cells in an allergic response.
Therefore, the correct answer is: Type-1 hypersensitivity reaction.
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