Concept:
A conjunction joins words or clauses and expresses their relationship.
Step 1: Understand the sentence meaning.
The sentence refers to events occurring from the time the speaker left school until now.
Step 2: Check the suitable conjunction.
The word:
\[
\text{Since}
\]
is used to indicate a point of time from the past continuing up to the present.
Step 3: Examine other options.
• As → indicates reason or manner
• If → conditional meaning
• from → preposition, not suitable here
Step 4: Write the correct sentence.
\[
\text{Many things have happened since I left school.}
\]
Step 5: Conclusion.
Thus, the correct answer is:
\[
\boxed{\text{Since}}
\]