Question:
Burkitt lymphoma is associated with:
Burkitt lymphoma is associated with:
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Which translocation puts MYC on chromosome 8 next to the IgH gene?
Updated On: Jun 24, 2026
- t(8;14)
- t(11;14)
- t(15;17)
- t(14;18)
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The Correct Option is A
Solution and Explanation
Step 1: Recall the Burkitt translocation.
Burkitt lymphoma is defined by a translocation that places the MYC oncogene on chromosome 8 next to an immunoglobulin gene. The classic and most common form is t(8;14), which juxtaposes MYC with the immunoglobulin heavy chain locus, causing constant MYC overexpression and rapid cell proliferation.
Step 2: Match the other translocations.
t(11;14) involves cyclin D1 and is seen in mantle cell lymphoma.
t(15;17) creates the PML-RARA fusion of acute promyelocytic leukemia (AML M3).
t(14;18) involves BCL2 and is the hallmark of follicular lymphoma.
Step 3: Conclusion.
Burkitt lymphoma is associated with t(8;14), option A.
Burkitt lymphoma is defined by a translocation that places the MYC oncogene on chromosome 8 next to an immunoglobulin gene. The classic and most common form is t(8;14), which juxtaposes MYC with the immunoglobulin heavy chain locus, causing constant MYC overexpression and rapid cell proliferation.
Step 2: Match the other translocations.
t(11;14) involves cyclin D1 and is seen in mantle cell lymphoma.
t(15;17) creates the PML-RARA fusion of acute promyelocytic leukemia (AML M3).
t(14;18) involves BCL2 and is the hallmark of follicular lymphoma.
Step 3: Conclusion.
Burkitt lymphoma is associated with t(8;14), option A.
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