Question:
Beta 2 receptors act via following secondary messenger
Beta 2 receptors act via following secondary messenger
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Beta-2 receptors are Gs-coupled GPCRs -- consider which enzyme is activated by the Gs protein.
Updated On: Jun 23, 2026
- Adenylate Cyclase
- Tyrosine kinase receptors
- TGF-beta receptors
- Cytokine receptors
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The Correct Option is A
Solution and Explanation
Beta-2 adrenergic receptors are G-protein coupled receptors (GPCRs) linked to the Gs subunit. When activated by agonists like adrenaline or salbutamol:
- Gs activates Adenylate Cyclase (Adenylyl Cyclase)
- Adenylate Cyclase converts ATP to cAMP
- cAMP activates Protein Kinase A (PKA), producing the cellular response
Other receptors for comparison:
- Tyrosine kinase receptors: growth factors (insulin, EGF, PDGF)
- TGF-beta receptors: serine/threonine kinase, SMAD pathway
- Cytokine receptors: JAK/STAT pathway
Answer: Beta-2 receptors act via Adenylate Cyclase (cAMP pathway).
- Gs activates Adenylate Cyclase (Adenylyl Cyclase)
- Adenylate Cyclase converts ATP to cAMP
- cAMP activates Protein Kinase A (PKA), producing the cellular response
Other receptors for comparison:
- Tyrosine kinase receptors: growth factors (insulin, EGF, PDGF)
- TGF-beta receptors: serine/threonine kinase, SMAD pathway
- Cytokine receptors: JAK/STAT pathway
Answer: Beta-2 receptors act via Adenylate Cyclase (cAMP pathway).
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