Question

Assertion (A): Denatured protein have decreased solubility. Reason (R): The hydrophobic groups are generally located inside protein molecules, during denaturation, these molecules get exposed onto molecule surface, which decreases the solubility.

• A. Both (A) and (R) are correct and (R) is the correct explanation of (A)
• B. Both (A) and (R) are correct but (R) is not the correct explanation of (A)
• C. (A) is correct but (R) is not correct
• D. (A) is not correct but (R) is correct

Hint:

Understanding the relationship between protein structure and its properties like solubility is crucial in biochemistry. Denaturation affects a protein's ability to interact with its environment, impacting various biological processes.

Answer 1

The Correct Option is A

Step 1: Concept
Denaturation refers to the process where proteins lose their native three-dimensional structure due to exposure to certain physical or chemical factors. This structural change can affect the protein's function, solubility, and other properties.

Step 2: Meaning
Solubility is the ability of a substance (solute) to dissolve in a solvent to form a homogeneous solution. In proteins, this means their capacity to remain dispersed in water or another medium without aggregating or precipitating out.

Step 3: Analysis
Assertion (A): Denatured protein have decreased solubility. - This statement is correct because denaturation disrupts the hydrogen bonds and other interactions that maintain a protein's native structure. Without these stabilizing forces, the hydrophobic regions of the protein are more exposed to the solvent. Reason (R): The hydrophobic groups are generally located inside protein molecules, during denaturation, these molecules get exposed onto molecule surface, which decreases the solubility. - This reason is also correct as it explains why denatured proteins become less soluble. When the hydrophobic regions are exposed to the solvent, they interact unfavorably with water, leading to decreased solubility.

Step 4: Conclusion
Both the assertion and the reason are correct, and the reason accurately explains the assertion. Final Answer: (A)