Question

Approaches to drug discovery and clinical trial of a compound:
A. Therapeutic confirmation/comparison
B. Micro dosing study
C. Human pharmacology and safety
D. Therapeutic exploration and dose ranging
E. Post marketing surveillance/data gathering
Choose the correct answer from the options given below:

• A. C, B, A, D, E
• B. B, C, D, A, E
• C. C, B, D, A, E
• D. D, A, C, B, E

Hint:

Microdose → Phase I → Phase II → Phase III → Phase IV

Answer 1

The Correct Option is B

Concept:
Drug development follows a systematic progression from early testing to post-marketing evaluation.

Step 1: Microdosing studies.

• Very small doses given to study pharmacokinetics Thus: \[ B: Micro dosing study \]

Step 2: Phase I – Human pharmacology.

• Safety and tolerability assessed Thus: \[ C: Human pharmacology and safety \]

Step 3: Phase II – Therapeutic exploration.

• Dose-response and efficacy studied Thus: \[ D: Therapeutic exploration and dose ranging \]

Step 4: Phase III – Confirmation.

• Large-scale comparison with standard treatments Thus: \[ A: Therapeutic confirmation \]

Step 5: Phase IV – Post-marketing.

• Long-term surveillance and adverse effects monitoring Thus: \[ E: Post marketing surveillance \]

Step 6: Final sequence.
\[ B \rightarrow C \rightarrow D \rightarrow A \rightarrow E \] \[ \boxed{\text{Correct answer = Option (2)}} \]