Step 1: Understanding immune complexes.
Antigen–antibody complexes are formed when antibodies bind specifically to antigens. These complexes must be cleared from circulation to prevent tissue damage.
Step 2: Importance of clearance mechanism.
If immune complexes are not removed, they can deposit in tissues. This may lead to inflammatory disorders such as hypersensitivity reactions.
Step 3: Role of monocytes/macrophages.
Monocytes differentiate into macrophages in tissues. They actively phagocytose and degrade antigen–antibody complexes from blood and tissues.
Step 4: Role of eosinophils.
Eosinophils help in immune regulation and participate in clearing antigen-antibody complexes, especially in parasitic and allergic conditions.
Step 5: Evaluation of other options.
Platelets are mainly involved in clotting, and RBCs transport gases. They do not participate in immune complex removal.
Step 6: Final conclusion.
Thus, antigen–antibody complexes are removed mainly by eosinophils and monocytes.