Question:
All of the following TCA cycle intermediates may be added or removed by other metabolic pathways except:
All of the following TCA cycle intermediates may be added or removed by other metabolic pathways except:
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Most TCA intermediates are "multitaskers," but Isocitrate usually stays in the cycle until it's converted to Alpha-ketoglutarate.
Updated On: May 28, 2026
- Isocitrate
- Fumarate
- Oxaloacetate
- Citrate
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The Correct Option is A
Solution and Explanation
Step 1: Concept
The TCA (Krebs) cycle is amphibolic, meaning it functions in both catabolism and anabolism.
Step 2: Meaning
Intermediates can enter or leave the cycle to participate in other pathways (Anaplerotic/Cataplerotic reactions).
Step 3: Analysis
Citrate (D) is used for fatty acid synthesis. Fumarate (B) and Oxaloacetate (C) are linked to the urea cycle and gluconeogenesis. Isocitrate (A) is the only intermediate in this list that does not typically serve as a major shunt for other pathways.
Step 4: Conclusion
Isocitrate is the exception.
Final Answer: (A)
The TCA (Krebs) cycle is amphibolic, meaning it functions in both catabolism and anabolism.
Step 2: Meaning
Intermediates can enter or leave the cycle to participate in other pathways (Anaplerotic/Cataplerotic reactions).
Step 3: Analysis
Citrate (D) is used for fatty acid synthesis. Fumarate (B) and Oxaloacetate (C) are linked to the urea cycle and gluconeogenesis. Isocitrate (A) is the only intermediate in this list that does not typically serve as a major shunt for other pathways.
Step 4: Conclusion
Isocitrate is the exception.
Final Answer: (A)
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