Question:
All glycosaminoglycans (GAGs) are covalently attached to protein as proteoglycans, except
All glycosaminoglycans (GAGs) are covalently attached to protein as proteoglycans, except
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Hyaluronan is the âLonerâ---no sulfate and no core protein partner.
Updated On: May 28, 2026
- Heparin
- Hyaluronan
- Chondroitin sulfate
- Keratan sulfate
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Verified By Collegedunia
The Correct Option is B
Solution and Explanation
Step 1: Concept
Glycosaminoglycans (GAGs) are long, unbranched polysaccharides consisting of repeating disaccharide units.
Step 2: Meaning
Most GAGs are synthesized in the Golgi and linked to a core protein to form proteoglycans.
Step 3: Analysis
Heparin, Chondroitin sulfate, and Keratan sulfate are all sulfated GAGs covalently bonded to proteins. Hyaluronan is unique: it is non-sulfated, synthesized at the plasma membrane, and does not covalently attach to a protein core.
Step 4: Conclusion
Hyaluronan is the only GAG listed that is not part of a proteoglycan complex.
Final Answer: (B)
Glycosaminoglycans (GAGs) are long, unbranched polysaccharides consisting of repeating disaccharide units.
Step 2: Meaning
Most GAGs are synthesized in the Golgi and linked to a core protein to form proteoglycans.
Step 3: Analysis
Heparin, Chondroitin sulfate, and Keratan sulfate are all sulfated GAGs covalently bonded to proteins. Hyaluronan is unique: it is non-sulfated, synthesized at the plasma membrane, and does not covalently attach to a protein core.
Step 4: Conclusion
Hyaluronan is the only GAG listed that is not part of a proteoglycan complex.
Final Answer: (B)
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