Step 1: Concept
The fraction of nuclei remaining after $n$ half-lives is $(\frac{1}{2})^n$.
Step 2: Analysis
Total time = 20 years. Half-life = 10 years.
Number of half-lives ($n$) = $20 / 10 = 2$.
Step 3: Calculation
Fraction remaining = $(\frac{1}{2})^2 = 1/4$.
Step 4: Conclusion
After 20 years, 1/4 of the sample remains.
Final Answer: (B)