Concept:
Plant layout is very important in pharmaceutical manufacturing because it affects quality, safety, and contamination control.
Step 1: Meaning of cross-contamination.
Cross-contamination occurs when one material contaminates another material or product.
Step 2: Role of material flow.
If material moves in multiple directions, chances of mixing, confusion, and contamination increase.
Step 3: Unidirectional flow.
Unidirectional material flow means materials move in one planned direction from raw material area to processing area to finished product area.
Step 4: Final answer.
Therefore, unidirectional material flow minimizes cross-contamination.
\[
\boxed{\text{Unidirectional material flow}}
\]