Question:
A humanized murine antibody is one in which the
A humanized murine antibody is one in which the
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• Humanized antibody = Mouse CDR + Human framework
• Reduces immune rejection
Updated On: May 13, 2026
- Heavy and light chain are from humans
- Heavy chain is from human and the light chain is from mouse
- Light chain is from human and the heavy chain is from mouse
- CDRs are from mouse and the other regions are from humans
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The Correct Option is D
Solution and Explanation
Concept:
Humanized antibodies are engineered to reduce immunogenicity while retaining antigen specificity.
• CDRs (Complementarity Determining Regions) determine antigen binding
• In humanized antibodies:
• CDRs are from mouse
• Framework regions are from human
Step 1: Understanding antibody engineering.
• Fully murine → high immunogenicity
• Chimeric → larger mouse portion
• Humanized → only CDRs from mouse
Step 2: Analyzing options.
• (A): Fully human antibody → Incorrect.
• (B) & (C): Mixed chains → not correct definition.
• (D): Mouse CDRs + human framework → Correct.
Step 3: Selecting the correct answer.
Thus, humanized antibodies have mouse CDRs and human constant/framework regions.
• CDRs (Complementarity Determining Regions) determine antigen binding
• In humanized antibodies:
• CDRs are from mouse
• Framework regions are from human
Step 1: Understanding antibody engineering.
• Fully murine → high immunogenicity
• Chimeric → larger mouse portion
• Humanized → only CDRs from mouse
Step 2: Analyzing options.
• (A): Fully human antibody → Incorrect.
• (B) & (C): Mixed chains → not correct definition.
• (D): Mouse CDRs + human framework → Correct.
Step 3: Selecting the correct answer.
Thus, humanized antibodies have mouse CDRs and human constant/framework regions.
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