Question

A highly potent low-dose drug requires which mixing equipment for content uniformity?

• A. Double cone blender
• B. Sigma mixer
• C. Turbine mixer
• D. Fluidized bed dryer

Hint:

For low-dose potent drugs, uniform dry powder blending is very important; double cone blender is commonly used for this purpose.

Answer 1

The Correct Option is A

Concept:
For potent low-dose drugs, uniform distribution of the active ingredient is very important because even a small variation can affect dose accuracy.

Step 1: Need for content uniformity.
Low-dose drugs are present in very small quantities. Therefore, proper blending is needed to distribute the drug uniformly throughout the powder mass.

Step 2: Double cone blender.
A double cone blender is commonly used for dry powder mixing. It provides gentle tumbling action and helps in achieving uniform mixing.

Step 3: Why other options are incorrect.
Sigma mixer is mainly used for wet mass and semisolid mixing.
Turbine mixer is mainly used for liquids.
Fluidized bed dryer is used for drying, not primarily for blending low-dose drugs.

Step 4: Final answer.
Thus, double cone blender is suitable for achieving content uniformity. \[ \boxed{\text{Double cone blender}} \]