\(5-HT_{2A/2C}\) antagonist used in migraine
\(5-HT_{2A/2C}\) antagonist used in migraine
Show Hint
- Methysergide
- Ketanserin
- Sumatriptan
- Rizatriptan
The Correct Option is A
Solution and Explanation
Methysergide is a serotonin receptor antagonist primarily targeting the \(5-HT_{2A}\) and \(5-HT_{2C}\) receptors. It has been used as a prophylactic treatment for migraine by preventing vasoconstriction and platelet aggregation associated with migraine attacks. - Methysergide blocks serotonin-induced vasoconstriction, thereby reducing migraine frequency.
- Ketanserin is also a \(5-HT_{2}\) antagonist but primarily used as an antihypertensive agent.
- Sumatriptan and Rizatriptan are \(5-HT_{1B/1D}\) receptor agonists (triptans) used for acute migraine treatment, not antagonists.
Hence, Methysergide is the correct drug categorized as a \(5-HT_{2A/2C}\) antagonist used in migraine prophylaxis.
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