List of top Medical Questions

A 32-year-old woman with relapsing-remitting multiple sclerosis presents with a positive Lhermitte sign indicating cervical cord involvement. She has low JC virus antibody titers and wishes to conceive in the future. Which of the following disease-modifying therapies is most appropriate for her?
A 48-year-old man undergoing chemotherapy for acute myeloid leukemia presents with high-grade fever, chills, and hypotension. Laboratory tests show an absolute neutrophil count (ANC) of 300 cells/$mm^3$. Blood cultures are pending. Which of the following organisms is most commonly responsible for sepsis in patients with febrile neutropenia?
A 28-year-old woman in her third trimester presents with jaundice, malaise, and elevated liver enzymes. Serology confirms Hepatitis E infection. Which of the following statements regarding Hepatitis E infection in pregnancy is true?
A 35-year-old man from Bihar presents with prolonged fever, weight loss, and hepatosplenomegaly. Laboratory findings show pancytopenia. Which of the following is considered the gold standard investigation for confirming the diagnosis of leishmaniasis?
A 28-year-old pregnant woman in her first trimester undergoes routine antenatal evaluation. Urine culture reveals $>$100,000 CFU/mL of E. coli, but she remains asymptomatic. What is the most appropriate next step in management?
A 45-year-old man on antitubercular therapy is found to have a rifampicin-resistant strain of Mycobacterium tuberculosis on GeneXpert testing. Which of the following best explains the mechanism of resistance?
A 7-year-old unvaccinated child presents with a history of sore throat and fever 3 weeks ago. The child now develops nasal regurgitation of fluids, facial deviation, and tongue weakness with numbness. On examination, there is palatal paralysis and a nasal twang to the voice. What is the most likely diagnosis?
A 42-year-old HIV-positive patient on antiretroviral therapy with stavudine presents with progressive motor weakness, tingling in the limbs, hepatomegaly, and metabolic acidosis. Laboratory evaluation shows elevated serum lactate levels, and neurological examination reveals large fiber sensory loss. What is the most likely diagnosis?
A 60-year-old man presents with high-grade fever, headache, neck stiffness, and altered sensorium. Cerebrospinal fluid (CSF) examination is pending, but clinical findings are highly suggestive of bacterial meningitis. Which empirical antibiotic regimen should be started immediately?
what is the most common cause of reactive arthritis in a patient with diarrhea and dysuria?
A 45-year-old man presents with chronic diarrhea, significant weight loss, and arthralgia. Endoscopic biopsy of the small intestine reveals numerous foamy macrophages in the lamina propria that stain positive with Periodic Acid–Schiff (PAS). What is the most likely diagnosis?
What is the drug of choice in the treatment of liver abscess?
A 22-year-old man presents with testicular pain and swelling 5 days after an episode of parotid gland enlargement and fever. Ultrasound confirms orchitis. He reports that he was not vaccinated in childhood. Which of the following statements regarding mumps orchitis is true?
A 38-year-old HIV-positive man with a CD4 count of 38 presents with fever and generalized tonic-clonic seizures. MRI brain reveals two ring-enhancing subcortical lesions without any specific differentiating features. What is the most likely diagnosis?
Understanding the pharmacokinetics of Amikacin is important because it helps clinicians to:
A 28-year-old veterinary worker who previously received a full 3-dose pre-exposure rabies vaccination series is bitten by a stray dog while handling an animal in the clinic. The wound is cleaned immediately. What is the most appropriate post-exposure management?
A 42-year-old patient undergoing chemotherapy for acute myeloid leukemia develops neutropenia (ANC $<$ 500) and is treated with broad-spectrum antibiotics. After initial recovery of neutrophil counts (ANC = 1500), he again develops high-grade fever and right upper quadrant abdominal pain. Imaging shows multiple small hypodense lesions in the liver and spleen. What is the most likely diagnosis?
A 32-year-old male recovering from dengue fever initially showed clinical improvement but now presents with recurrence of high-grade fever, fatigue, and pancytopenia on day 10 of illness. He is hemodynamically stable with no bleeding manifestations. Which of the following investigations should be performed first to evaluate the cause of relapse and cytopenia?
A 48-year-old man with chronic hepatitis C infection is being evaluated for risk factors associated with progression of liver disease. He has a 20-year history of infection, drinks alcohol occasionally, and has a high serum HCV RNA viral load. Which of the following factors is not associated with an increased risk of progression of liver disease in chronic HCV infection?
A liver transplant patient presents with diarrhoea, colitis, a total leukocyte count of 1800, and a positive blood CMV PCR. What is the next step in management?