Step 1: General trend of P-wave velocity.
As depth increases, pressure and density generally cause P-wave velocity to increase inside the Earth. However, sharp changes occur at certain boundaries due to changes in the state of matter.
Step 2: Crust–mantle boundary (MohoroviÄić discontinuity).
Here, velocity \emph{increases} because mantle rocks are denser than crustal rocks. No decrease is observed.
Step 3: Mantle–outer core boundary.
At this boundary, the medium changes from solid mantle to liquid outer core. Since P-waves travel more slowly in liquids than in solids, their velocity shows a sharp and significant \emph{decrease}. This is the main cause of the seismic P-wave shadow zone.
Step 4: Outer core–inner core boundary.
At this boundary, P-wave velocity actually \emph{increases} slightly again because the inner core is solid.
Step 5: Upper mantle–lower mantle.
P-wave velocity increases gradually with depth; there is no sudden decrease.
Final Answer: The significant decrease in P-wave velocity occurs at the mantle–outer core boundary.
\[
\boxed{\text{Mantle–Outer Core}}
\]