Question:
Which structural feature is essential for opioid analgesic activity?
Which structural feature is essential for opioid analgesic activity?
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Opioid painkillers, like morphine, fit into special opioid receptors in the body. Certain parts of the molecule are needed for this binding and for good pain relief.
Updated On: Jun 24, 2026
- Carboxylic acid group
- Phenolic hydroxyl group
- Ester Linkage
- Sulfonemide group
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The Correct Option is B
Solution and Explanation
Concept:
Opioid painkillers, like morphine, fit into special opioid receptors in the body. Certain parts of the molecule are needed for this binding and for good pain relief.
Step 1:
A key part of morphine and similar opioids is the phenolic hydroxyl group (an -OH attached to an aromatic ring). This group helps the drug bind to the receptor and is important for strong analgesic activity.
Step 2:
A carboxylic acid group, an ester linkage, or a sulfonamide group are not the essential feature for opioid pain relief, so the other options are incorrect.
Answer: Option (2) — Phenolic hydroxyl group.
Opioid painkillers, like morphine, fit into special opioid receptors in the body. Certain parts of the molecule are needed for this binding and for good pain relief.
Step 1:
A key part of morphine and similar opioids is the phenolic hydroxyl group (an -OH attached to an aromatic ring). This group helps the drug bind to the receptor and is important for strong analgesic activity.
Step 2:
A carboxylic acid group, an ester linkage, or a sulfonamide group are not the essential feature for opioid pain relief, so the other options are incorrect.
Answer: Option (2) — Phenolic hydroxyl group.
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