Question:
Which option best explains the LDH flipped (flipping) pattern?
Which option best explains the LDH flipped (flipping) pattern?
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After an MI the heart isoenzyme overtakes the normally dominant serum one.
Updated On: Jun 24, 2026
- LDH 1 > LDH 2
- LDH 2 > LDH 1
- LDH 2 > LDH 3
- LDH 3 > LDH 2
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The Correct Option is A
Solution and Explanation
Step 1: Lactate dehydrogenase is a tetramer with H (heart) and M (muscle) subunits, giving five isoenzymes. LDH-1 (4H) predominates in the heart and red cells, while LDH-2 (3H1M) normally predominates in serum. Step 2: Normally the serum shows LDH-2 greater than LDH-1. Step 3: After myocardial infarction, damaged cardiac tissue releases large amounts of LDH-1 into the blood, so LDH-1 becomes greater than LDH-2. This reversal is called the flipped or flipping pattern. Step 4: Hence the flip is defined by LDH 1 greater than LDH 2, making option A correct; the other options do not describe this cardiac reversal.
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