The question requires us to identify which organelle is enclosed by a single membrane. Let's examine each option:
- Ribosome: Ribosomes are not surrounded by any membrane. They are composed of RNA and proteins and are involved in protein synthesis.
- Mitochondria: Mitochondria are double-membraned organelles with an outer and an inner membrane. They are the powerhouse of the cell.
- Endoplasmic Reticulum (ER): The ER is an organelle that is enclosed by a single membrane. It plays a crucial role in the synthesis of proteins and lipids.
- Centrosome: Centrosomes typically do not have a membrane. They play a crucial role in cell division and contain microtubule-organizing centers.
From the analysis above, the only organelle enclosed by a single membrane is the Endoplasmic Reticulum (ER). Thus, the correct answer is Endoplasmic Reticulum.