Question

Which one of the following mechanisms is expected to generate tightly linked genes?

• A. Chromosomal inversion
• B. Deletion of an exon
• C. Gene duplication
• D. Insertion of an exon

Hint:

Chromosomal inversion leads to tight linkage of genes within the inverted segment due to the prevention of recombination.

Answer 1

The Correct Option is A

Step 1: Chromosomal inversion.
Chromosomal inversions can result in tightly linked genes because the genes that are part of the inverted region will tend to be inherited together due to the altered structure of the chromosome. This prevents recombination between the genes in the inverted segment, effectively linking them.
Step 2: Explanation of the other options.
Gene duplication involves the creation of multiple gene copies, but this does not necessarily result in tight linkage. It can lead to paralogs that may diverge over time.
Deletion or insertion of an exon can affect gene structure but does not generate tightly linked genes.