Question:
Which of the following substances is used as an inactivating agent for sulfonamides?
Which of the following substances is used as an inactivating agent for sulfonamides?
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Sulfonamides mimic PABA → PABA excess = sulfonamide inactivation.
Updated On: May 22, 2025
- PABA (Para Amino Benzoic Acid)
- Penicillinase
- Acetyl Transferase
- Penicillamine
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The Correct Option is A
Solution and Explanation
PABA competes with sulfonamides for incorporation into folic acid synthesis in bacteria. Because sulfonamides act as PABA analogs, an excess of PABA can inactivate or reduce the effectiveness of sulfonamides.
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