Question:
Which of the following statements about opioid receptor antagonists is false?
Which of the following statements about opioid receptor antagonists is false?
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Compare potency and duration: which antagonist is short acting and parenteral versus orally active and long lasting?
Updated On: Jun 24, 2026
- Naloxone can be used for treatment of opioid induced constipation
- Naltrexone may be used for treatment of alcohol dependence
- Nalmefene has a longer half life than naloxone
- Naloxone is more potent than naltrexone
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The Correct Option is D
Solution and Explanation
Step 1: Understand the task. We must find the FALSE statement about opioid antagonists.
Step 2: Check option A. Naloxone, especially in poorly absorbed oral or peripherally restricted forms, blocks gut opioid receptors and relieves opioid induced constipation without reversing central analgesia. This statement is TRUE.
Step 3: Check option B. Naltrexone reduces craving and is an approved treatment for alcohol dependence. This statement is TRUE.
Step 4: Check option C. Nalmefene is long acting with a half life of around 8 to 11 hours, much longer than naloxone, whose half life is only about 1 to 2 hours. This statement is TRUE.
Step 5: Check option D. On a milligram basis naltrexone is actually more potent and longer acting than naloxone; naloxone is short acting and given mainly parenterally. So the claim that naloxone is more potent than naltrexone is FALSE.
Step 6: The question asks for the false statement, so option D is the answer.
Answer: Option D.
Step 2: Check option A. Naloxone, especially in poorly absorbed oral or peripherally restricted forms, blocks gut opioid receptors and relieves opioid induced constipation without reversing central analgesia. This statement is TRUE.
Step 3: Check option B. Naltrexone reduces craving and is an approved treatment for alcohol dependence. This statement is TRUE.
Step 4: Check option C. Nalmefene is long acting with a half life of around 8 to 11 hours, much longer than naloxone, whose half life is only about 1 to 2 hours. This statement is TRUE.
Step 5: Check option D. On a milligram basis naltrexone is actually more potent and longer acting than naloxone; naloxone is short acting and given mainly parenterally. So the claim that naloxone is more potent than naltrexone is FALSE.
Step 6: The question asks for the false statement, so option D is the answer.
Answer: Option D.
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