Question:
Endothelin acts through which second messenger / receptor pathway?
Endothelin acts through which second messenger / receptor pathway?
Show Hint
Endothelin acting on endothelial receptors releases NO, which raises this cyclic nucleotide.
Updated On: Jun 24, 2026
- cAMP
- cGMP
- Na+ receptors
- Calcium receptors
Show Solution
Verified By Collegedunia
The Correct Option is B
Solution and Explanation
Step 1: Recall endothelin biology. Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor secreted by endothelial cells, acting on \(ET_A\) and \(ET_B\) receptors.
Step 2: Trace the messenger. Stimulation of endothelial \(ET_B\) receptors releases nitric oxide, which raises cyclic GMP (cGMP) in vascular smooth muscle and modulates the vascular response.
Step 3: Match the option text. The intended answer in the key is cGMP, which corresponds to option B.
Step 4: Exclude distractors. cAMP, sodium receptors, and calcium receptors are not the signaling route highlighted for endothelin in this item.
Step 2: Trace the messenger. Stimulation of endothelial \(ET_B\) receptors releases nitric oxide, which raises cyclic GMP (cGMP) in vascular smooth muscle and modulates the vascular response.
Step 3: Match the option text. The intended answer in the key is cGMP, which corresponds to option B.
Step 4: Exclude distractors. cAMP, sodium receptors, and calcium receptors are not the signaling route highlighted for endothelin in this item.
Was this answer helpful?
0
0
Top NEET PG Pharmacology Questions
- A bronchial asthma patient on inhalational steroids presented with white patchy lesions on the tongue and buccal mucosa. What is the drug that can be used to treat this condition?
- A pregnant woman with a history of bronchial asthma is in the third stage of labor. Which drugs should be avoided in managing postpartum hemorrhage in this mother?
- Name the drug that acts on both the marked areas.
- A patient with a previous history of myocardial infarction and ventricular arrhythmia is ontreatment for a few months. He developed fatigue, dyspnea, and weight gain. He had also developed pulmonary fibrosis. Which of the following drugs is responsible for the side effects mentioned above?
- A young female comes to the emergency department after consuming 100 aspirin tablets.What should be the next step in management?
View More Questions
Top NEET PG Autacoids and their Antagonists Questions
- A young female comes to the emergency department after consuming 100 aspirin tablets.What should be the next step in management?
- A patient with recurrent gout attacks was started on a therapy that inhibits uric acid synthesis.His symptoms were reduced after therapy. Which drug was he started on ?
- Which drug acts via the tyrosine kinase receptor?
- Endothelin acts through which receptors?
Top NEET PG Questions
- A patient hailing from Delhi presents with fever, arthralgia, and extensive petechial rash for 3 days. Lab investigations revealed a hemoglobin of 9 g/ dL, a white blood cell count of 9000 cells/mm3, a platelet count of 20000 cells/mm3, and a prolonged bleeding time. The clotting time was normal. What is the most likely diagnosis?
- Which of the following statements is true about Trichomonas vaginalis?
- A lady from West Rajasthan presented with an ulcer surrounded by erythema on the right leg. Microscopy of the biopsy from the edge of the ulcer showed organisms with dark staining nuclei and kinetoplast. What is the most likely causative agent?
- A child presents with a fever and a rash. Urine examination showed cells with owl's eye appearance. What is the most likely diagnosis?
- Infection with Clonorchis sinensis is associated with an increased risk of__?
View More Questions