Question:
Which of the following is true about polyarteritis nodosa (PAN)?
Which of the following is true about polyarteritis nodosa (PAN)?
Show Hint
One classic association of medium-vessel PAN is a viral hepatitis seen in roughly a third of patients; PAN is ANCA-negative.
Updated On: Jun 23, 2026
- Microscopy shows fibrinoid necrosis in large arteries
- ANCA is positive
- About 30% of patients have HBsAg positivity
- Patients have hypogammaglobulinaemia
Show Solution
Verified By Collegedunia
The Correct Option is C
Solution and Explanation
Correct answer: About 30% of patients have HBsAg positivity.
Step 1: PAN is a necrotizing vasculitis of small and medium-sized muscular arteries. About 30% of patients have chronic hepatitis B with HBsAg-HBsAb immune complexes deposited in vessel walls, pointing to an immune-complex mechanism in that subset.
Step 2: Why the others are wrong. PAN affects small and medium arteries, not large arteries, so option 1 is incorrect. PAN is classically ANCA-negative, which distinguishes it from microscopic polyangiitis and granulomatosis with polyangiitis, so option 2 is wrong. PAN is an immune-complex disease and does not cause hypogammaglobulinaemia, so option 4 is wrong.
Step 3: Kidneys, heart, gastrointestinal tract, and muscle are commonly involved; lungs are characteristically spared.
Ref: Robbins, vasculitis.
Step 1: PAN is a necrotizing vasculitis of small and medium-sized muscular arteries. About 30% of patients have chronic hepatitis B with HBsAg-HBsAb immune complexes deposited in vessel walls, pointing to an immune-complex mechanism in that subset.
Step 2: Why the others are wrong. PAN affects small and medium arteries, not large arteries, so option 1 is incorrect. PAN is classically ANCA-negative, which distinguishes it from microscopic polyangiitis and granulomatosis with polyangiitis, so option 2 is wrong. PAN is an immune-complex disease and does not cause hypogammaglobulinaemia, so option 4 is wrong.
Step 3: Kidneys, heart, gastrointestinal tract, and muscle are commonly involved; lungs are characteristically spared.
Ref: Robbins, vasculitis.
Was this answer helpful?
0
0
Top NEET PG Pathology Questions
- Which of the following is true regarding the Mendelian mode of inheritance?
- A child presents with intermittent jaundice and splenomegaly. There is a history of similar complaints in the elder brother. Peripheral smear shows the following finding. How will you investigate this condition?
- An African child is found to have a mass in the jaw. A biopsy of the mass was done, and it appears as shown in the image below. The child also had a translocation of t(8;14). What is the probable diagnosis?
- A child presented to the hospital with cola-colored urine, hypertension, and puffiness of eyes. Laboratory investigations were done, and creatinine was 2.5 mg/dL. Treatment was started, and despite treatment, the patient did not improve for the next 3 weeks. The creatinine value increased to 4.5 mg/dL. Which among the following electron microscopic findings will be seen in this patient ?
- A patient was transfused 4 units of blood 2 hours ago, and now she complains of chest discomfort. X-ray shows bilateral fissural thickening. Which of the following is the most probable cause ?
View More Questions
Top NEET PG Vasculitis Questions
Top NEET PG Questions
- A patient hailing from Delhi presents with fever, arthralgia, and extensive petechial rash for 3 days. Lab investigations revealed a hemoglobin of 9 g/ dL, a white blood cell count of 9000 cells/mm3, a platelet count of 20000 cells/mm3, and a prolonged bleeding time. The clotting time was normal. What is the most likely diagnosis?
- Which of the following statements is true about Trichomonas vaginalis?
- A lady from West Rajasthan presented with an ulcer surrounded by erythema on the right leg. Microscopy of the biopsy from the edge of the ulcer showed organisms with dark staining nuclei and kinetoplast. What is the most likely causative agent?
- A child presents with a fever and a rash. Urine examination showed cells with owl's eye appearance. What is the most likely diagnosis?
- Infection with Clonorchis sinensis is associated with an increased risk of__?
View More Questions