Question:
Which of the following is not the source of cytosolic NADPH ?
Which of the following is not the source of cytosolic NADPH ?
Updated On: Jul 14, 2025
- Isocitrate dehydrogenase
- ATP citrate lyase
- Malic enzyme
- G6PD
Show Solution
Verified By Collegedunia
The Correct Option is B
Solution and Explanation
To determine which option is not a source of cytosolic NADPH, we need to understand the enzymes that contribute to the production of NADPH in the cell cytosol:
| Enzyme | Role in NADPH Production |
|---|---|
| Isocitrate dehydrogenase | Uses the conversion of isocitrate to α-ketoglutarate in the cytosol to generate NADPH. |
| ATP citrate lyase | This enzyme catalyzes the conversion of citrate to acetyl-CoA and oxaloacetate. It does not directly produce NADPH. |
| Malic enzyme | Converts malate to pyruvate while generating NADPH in the process. |
| G6PD (Glucose-6-phosphate dehydrogenase) | The key enzyme in the pentose phosphate pathway, produces NADPH. |
Based on this information, ATP citrate lyase does not produce NADPH in the cytosol. This enzyme's primary function is in the conversion of citrate, facilitating fatty acid synthesis, but it does not have a role in NADPH production. Therefore, the option that is not a source of cytosolic NADPH is ATP citrate lyase.
Was this answer helpful?
0
0
Top NEET (PG) Biochemistry Questions
- Which of the following clotting factors is needed for gamma-glutamyl carboxylase?
- A patient presented with diarrhea, dermatitis, and dementia. Which of the following vitamin deficiencies would you suspect in this patient?
- A young boy presents to the OPD with hypoglycemia and muscle cramps, on exertion or while playing. Then he becomes normal after resting for a while. These episodes are recurrent after a period of activity. He has decreased serum lactate and glucose levels. Which of the following diseases is he most likely to be suffering from?
- A family consumes only polished rice. Which of the following combinations of vitamin deficiency and enzymatic defect will be present in this family?
- A chronic alcoholic patient presented to the casualty with confusion, ataxia, and painful eye movements. What could be the vitamin deficiency seen in this patient?
View More Questions
Top NEET (PG) Regulation of major metabolic pathways Questions
Top NEET (PG) Questions
- A patient hailing from Delhi presents with fever, arthralgia, and extensive petechial rash for 3 days. Lab investigations revealed a hemoglobin of 9 g/ dL, a white blood cell count of 9000 cells/mm3, a platelet count of 20000 cells/mm3, and a prolonged bleeding time. The clotting time was normal. What is the most likely diagnosis?
- Which of the following statements is true about Trichomonas vaginalis?
- A lady from West Rajasthan presented with an ulcer surrounded by erythema on the right leg. Microscopy of the biopsy from the edge of the ulcer showed organisms with dark staining nuclei and kinetoplast. What is the most likely causative agent?
- A child presents with a fever and a rash. Urine examination showed cells with owl's eye appearance. What is the most likely diagnosis?
- Infection with Clonorchis sinensis is associated with an increased risk of__?
View More Questions