Question:
Which of the following is NOT an autoimmune disease?
Which of the following is NOT an autoimmune disease?
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Three are antibody-mediated self-attacks; one is a single-gene haemoglobin defect.
Updated On: Jun 24, 2026
- Systemic lupus erythematosus (SLE)
- Grave's disease
- Myasthenia gravis
- Sickle cell disease
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The Correct Option is D
Solution and Explanation
Step 1: An autoimmune disease results when the immune system loses self-tolerance and produces autoantibodies or autoreactive T cells directed against the body's own antigens.
Step 2: SLE is a classic systemic autoimmune disease driven by antinuclear and anti-dsDNA antibodies forming immune complexes.
Step 3: Grave's disease is an organ-specific autoimmune disorder in which stimulating autoantibodies bind the TSH receptor, causing hyperthyroidism.
Step 4: Myasthenia gravis is autoimmune, caused by antibodies against the nicotinic acetylcholine receptor at the neuromuscular junction.
Step 5: Sickle cell disease is an autosomal recessive genetic disorder caused by a point mutation in the beta-globin gene (HbS), with no autoimmune mechanism.
Conclusion: Sickle cell disease is the odd one out, so the answer is option 4.
Step 2: SLE is a classic systemic autoimmune disease driven by antinuclear and anti-dsDNA antibodies forming immune complexes.
Step 3: Grave's disease is an organ-specific autoimmune disorder in which stimulating autoantibodies bind the TSH receptor, causing hyperthyroidism.
Step 4: Myasthenia gravis is autoimmune, caused by antibodies against the nicotinic acetylcholine receptor at the neuromuscular junction.
Step 5: Sickle cell disease is an autosomal recessive genetic disorder caused by a point mutation in the beta-globin gene (HbS), with no autoimmune mechanism.
Conclusion: Sickle cell disease is the odd one out, so the answer is option 4.
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