Question:
Which of the following is not an adverse effect of thalidomide?
Which of the following is not an adverse effect of thalidomide?
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Thalidomide slows the gut and causes constipation, not loose stools.
Updated On: Jun 24, 2026
- Diarrhoea
- Teratogenicity
- DVT
- Hypothyroidism
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The Correct Option is A
Solution and Explanation
Step 1: The question asks for the option that is NOT a recognised adverse effect of thalidomide.
Step 2: Teratogenicity is the most notorious effect: thalidomide caused phocomelia (seal-like limb defects), making it absolutely contraindicated in pregnancy. This is a true adverse effect.
Step 3: Deep vein thrombosis (DVT) and venous thromboembolism are well-documented adverse effects, particularly when thalidomide is combined with dexamethasone or chemotherapy in multiple myeloma; thromboprophylaxis is often advised. This is a true adverse effect.
Step 4: Hypothyroidism is also reported with thalidomide therapy and is a recognised adverse effect.
Step 5: Regarding the gastrointestinal tract, thalidomide characteristically causes CONSTIPATION, not diarrhoea. Therefore diarrhoea is the option that is NOT an adverse effect of thalidomide.
Conclusion: The correct answer is Diarrhoea, matching the printed key.
Step 2: Teratogenicity is the most notorious effect: thalidomide caused phocomelia (seal-like limb defects), making it absolutely contraindicated in pregnancy. This is a true adverse effect.
Step 3: Deep vein thrombosis (DVT) and venous thromboembolism are well-documented adverse effects, particularly when thalidomide is combined with dexamethasone or chemotherapy in multiple myeloma; thromboprophylaxis is often advised. This is a true adverse effect.
Step 4: Hypothyroidism is also reported with thalidomide therapy and is a recognised adverse effect.
Step 5: Regarding the gastrointestinal tract, thalidomide characteristically causes CONSTIPATION, not diarrhoea. Therefore diarrhoea is the option that is NOT an adverse effect of thalidomide.
Conclusion: The correct answer is Diarrhoea, matching the printed key.
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