Question:
Which cephalosporin characteristically causes thrombocytopenia?
Which cephalosporin characteristically causes thrombocytopenia?
Show Hint
Pair low platelets and low neutrophils with the antipseudomonal third-generation agent.
Updated On: Jun 24, 2026
- Cefixime
- Ceftazidime
- Cefoperazone
- Cefdinir
Show Solution
Verified By Collegedunia
The Correct Option is B
Solution and Explanation
Step 1: Cephalosporins share a class of adverse effects (hypersensitivity, diarrhea, superinfection) but several individual agents have signature toxicities. Recognising the drug tied to a specific effect is the key to this question.
Step 2: Ceftazidime is the cephalosporin classically linked with haematological suppression, producing neutropenia and thrombocytopenia. That makes option b the correct answer.
Step 3: The distractors carry different signatures. Cefoperazone (like ceftriaxone, cefamandole and moxalactam) is associated with hypoprothrombinaemia and bleeding from its methylthiotetrazole side chain and biliary excretion, plus a disulfiram-like reaction with alcohol, but not specifically thrombocytopenia. Cefixime and cefdinir are oral third-generation agents whose main issue is gastrointestinal upset, not platelet suppression.
Step 2: Ceftazidime is the cephalosporin classically linked with haematological suppression, producing neutropenia and thrombocytopenia. That makes option b the correct answer.
Step 3: The distractors carry different signatures. Cefoperazone (like ceftriaxone, cefamandole and moxalactam) is associated with hypoprothrombinaemia and bleeding from its methylthiotetrazole side chain and biliary excretion, plus a disulfiram-like reaction with alcohol, but not specifically thrombocytopenia. Cefixime and cefdinir are oral third-generation agents whose main issue is gastrointestinal upset, not platelet suppression.
Was this answer helpful?
0
0
Top NEET PG Pharmacology Questions
- A bronchial asthma patient on inhalational steroids presented with white patchy lesions on the tongue and buccal mucosa. What is the drug that can be used to treat this condition?
- A pregnant woman with a history of bronchial asthma is in the third stage of labor. Which drugs should be avoided in managing postpartum hemorrhage in this mother?
- Name the drug that acts on both the marked areas.
- A patient with a previous history of myocardial infarction and ventricular arrhythmia is ontreatment for a few months. He developed fatigue, dyspnea, and weight gain. He had also developed pulmonary fibrosis. Which of the following drugs is responsible for the side effects mentioned above?
- A young female comes to the emergency department after consuming 100 aspirin tablets.What should be the next step in management?
View More Questions
Top NEET PG Cephalosporins - adverse effects Questions
Top NEET PG Questions
- A patient hailing from Delhi presents with fever, arthralgia, and extensive petechial rash for 3 days. Lab investigations revealed a hemoglobin of 9 g/ dL, a white blood cell count of 9000 cells/mm3, a platelet count of 20000 cells/mm3, and a prolonged bleeding time. The clotting time was normal. What is the most likely diagnosis?
- Which of the following statements is true about Trichomonas vaginalis?
- A lady from West Rajasthan presented with an ulcer surrounded by erythema on the right leg. Microscopy of the biopsy from the edge of the ulcer showed organisms with dark staining nuclei and kinetoplast. What is the most likely causative agent?
- A child presents with a fever and a rash. Urine examination showed cells with owl's eye appearance. What is the most likely diagnosis?
- Infection with Clonorchis sinensis is associated with an increased risk of__?
View More Questions