Question:
Which of the following is/are involved in the initiation of DNA replication?
Which of the following is/are involved in the initiation of DNA replication?
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Replication starts at {oriC} with the help of {DnaA}, which opens the double helix.
Helicase and primase follow to form the replication fork.
Updated On: Dec 5, 2025
- RhoA
- oriC
- Sigma factor
- DnaA
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The Correct Option is B, D
Solution and Explanation
Step 1: Recall replication initiation in prokaryotes.
DNA replication begins at a specific sequence called the origin of replication (oriC).
Step 2: Role of DnaA.
The DnaA protein binds to oriC and unwinds the DNA, allowing helicase and primase to initiate replication.
Step 3: Eliminate unrelated factors.
- RhoA: Involved in transcription termination.
- Sigma factor: A transcription initiation factor, not replication.
Step 4: Conclusion.
Hence, the correct answer is (B) oriC and (D) DnaA.
DNA replication begins at a specific sequence called the origin of replication (oriC).
Step 2: Role of DnaA.
The DnaA protein binds to oriC and unwinds the DNA, allowing helicase and primase to initiate replication.
Step 3: Eliminate unrelated factors.
- RhoA: Involved in transcription termination.
- Sigma factor: A transcription initiation factor, not replication.
Step 4: Conclusion.
Hence, the correct answer is (B) oriC and (D) DnaA.
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