Question:
Which of the following is/are extra-cellular matrix protein(s)?
Which of the following is/are extra-cellular matrix protein(s)?
Show Hint
Ask whether the protein is secreted outside the cell or works inside the cytoplasm/nucleus; only secreted structural or adhesive proteins count as ECM proteins.
Updated On: Aug 7, 2026
- Myosin
- Fibronectin
- Lamin
- Collagen
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Verified By Collegedunia
The Correct Option is B, D
Solution and Explanation
Step 1: Understanding the Question:
The question asks which listed proteins sit outside the cell, in the extracellular matrix (ECM), rather than inside the cell or the nucleus.
Step 2: Key Formula or Approach:
The ECM is the network of proteins and polysaccharides that a cell secretes into the space around it. Its main proteins are structural fibers like collagen, plus adhesive glycoproteins like fibronectin and laminin. Proteins that work inside the cell (motor proteins, nuclear scaffold proteins) are not ECM components even when their names sound similar to ECM proteins.
Step 3: Detailed Explanation:
Option (A) Myosin is a motor protein that stays inside the cell. It binds actin and drives muscle contraction and other force-generating movements, and it is never secreted into the ECM, so this option is wrong.
Option (B) Fibronectin is a large glycoprotein that the cell secretes into the ECM. It has separate binding sites for collagen, fibrin and the integrin receptors on the cell surface, so it links the cell to the matrix around it. This makes it a genuine ECM protein, so this option is correct.
Option (C) Lamin is not the same molecule as laminin. Lamins are intermediate filament proteins that build the nuclear lamina, a mesh lining the inside of the nuclear envelope. Since lamin stays inside the nucleus, it is not an ECM protein, so this option is wrong.
Option (D) Collagen is the most abundant structural protein of the ECM. It self-assembles into triple helical fibers that give connective tissue its tensile strength, so this option is correct.
Step 4: Final Answer:
The extra-cellular matrix proteins among the choices are Fibronectin and Collagen, options (B) and (D). \[ \boxed{\text{Fibronectin and Collagen}} \]
The question asks which listed proteins sit outside the cell, in the extracellular matrix (ECM), rather than inside the cell or the nucleus.
Step 2: Key Formula or Approach:
The ECM is the network of proteins and polysaccharides that a cell secretes into the space around it. Its main proteins are structural fibers like collagen, plus adhesive glycoproteins like fibronectin and laminin. Proteins that work inside the cell (motor proteins, nuclear scaffold proteins) are not ECM components even when their names sound similar to ECM proteins.
Step 3: Detailed Explanation:
Option (A) Myosin is a motor protein that stays inside the cell. It binds actin and drives muscle contraction and other force-generating movements, and it is never secreted into the ECM, so this option is wrong.
Option (B) Fibronectin is a large glycoprotein that the cell secretes into the ECM. It has separate binding sites for collagen, fibrin and the integrin receptors on the cell surface, so it links the cell to the matrix around it. This makes it a genuine ECM protein, so this option is correct.
Option (C) Lamin is not the same molecule as laminin. Lamins are intermediate filament proteins that build the nuclear lamina, a mesh lining the inside of the nuclear envelope. Since lamin stays inside the nucleus, it is not an ECM protein, so this option is wrong.
Option (D) Collagen is the most abundant structural protein of the ECM. It self-assembles into triple helical fibers that give connective tissue its tensile strength, so this option is correct.
Step 4: Final Answer:
The extra-cellular matrix proteins among the choices are Fibronectin and Collagen, options (B) and (D). \[ \boxed{\text{Fibronectin and Collagen}} \]
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