Question

Which of the following causes melanosis coli?

• A. Senna
• B. Sorbitol
• C. Magnesium Sulphate
• D. Bisacodyl

Answer 1

The Correct Option is A

Melanosis coli is a condition characterized by a dark pigment deposition in the colon, which is often associated with the long-term use of certain stimulant laxatives. The condition itself is benign and does not pose a direct health threat, but it is an indication of prolonged laxative use, which may suggest laxative abuse or dependency issues.

Among the options provided:

• Senna: A stimulant laxative commonly used to treat constipation. Long-term use of senna can cause melanosis coli due to the presence of anthraquinone compounds that lead to the accumulation of pigment in the colon.
• Sorbitol: A sugar alcohol with laxative effects that does not cause melanosis coli.
• Magnesium Sulphate: Also known as Epsom salt, commonly used as a laxative, it does not cause melanosis coli.
• Bisacodyl: A stimulant laxative similar to senna in its function but less commonly associated with melanosis coli compared to senna.

Therefore, the correct answer is Senna, as it is responsible for causing melanosis coli due to its anthraquinone content.