Question:
Which medication is added to prolong the activity of L-DOPA in the case of motor fluctuation development?
Which medication is added to prolong the activity of L-DOPA in the case of motor fluctuation development?
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COMT inhibitors are adjuncts to L-DOPA that enhance and prolong its therapeutic effect.
Updated On: May 22, 2025
- MAO-B inhibitors
- Catechol-O-methyl transferase inhibitor
- Dopamine inhibitors
- Anti-cholinergic
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The Correct Option is B
Solution and Explanation
Catechol-O-methyl transferase (COMT) inhibitors, like entacapone, reduce the peripheral metabolism of L-DOPA, thereby extending its half-life and effectiveness in managing motor fluctuations in Parkinson’s disease.
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