Question:
Which is the first purine nucleotide synthesized in purine biosynthesis?
Which is the first purine nucleotide synthesized in purine biosynthesis?
Show Hint
The ring is assembled on ribose; the first complete purine nucleotide carries hypoxanthine.
Updated On: Jun 24, 2026
- AMP
- GMP
- IMP
- UMP
Show Solution
Verified By Collegedunia
The Correct Option is C
Solution and Explanation
Step 1: In de novo purine biosynthesis the purine ring is built up step by step on a ribose-5-phosphate backbone (derived from the pentose phosphate pathway), which is first activated to PRPP.
Step 2: The end product of this assembly is inosine monophosphate (IMP), whose base is hypoxanthine. IMP is therefore the first complete purine nucleotide formed.
Step 3: IMP is the common precursor: it is then converted into AMP (via adenylosuccinate) and into GMP (via xanthosine monophosphate). So AMP and GMP form after IMP and cannot be the first.
Step 4: UMP is wrong because it is a pyrimidine nucleotide, not a purine, and so does not belong to the purine pathway at all.
Step 2: The end product of this assembly is inosine monophosphate (IMP), whose base is hypoxanthine. IMP is therefore the first complete purine nucleotide formed.
Step 3: IMP is the common precursor: it is then converted into AMP (via adenylosuccinate) and into GMP (via xanthosine monophosphate). So AMP and GMP form after IMP and cannot be the first.
Step 4: UMP is wrong because it is a pyrimidine nucleotide, not a purine, and so does not belong to the purine pathway at all.
Was this answer helpful?
0
0
Top NEET PG Biochemistry Questions
- Which of the following clotting factors is needed for gamma-glutamyl carboxylase?
- A patient presented with diarrhea, dermatitis, and dementia. Which of the following vitamin deficiencies would you suspect in this patient?
- A young boy presents to the OPD with hypoglycemia and muscle cramps, on exertion or while playing. Then he becomes normal after resting for a while. These episodes are recurrent after a period of activity. He has decreased serum lactate and glucose levels. Which of the following diseases is he most likely to be suffering from?
- A family consumes only polished rice. Which of the following combinations of vitamin deficiency and enzymatic defect will be present in this family?
- A chronic alcoholic patient presented to the casualty with confusion, ataxia, and painful eye movements. What could be the vitamin deficiency seen in this patient?
View More Questions
Top NEET PG Questions
- A patient hailing from Delhi presents with fever, arthralgia, and extensive petechial rash for 3 days. Lab investigations revealed a hemoglobin of 9 g/ dL, a white blood cell count of 9000 cells/mm3, a platelet count of 20000 cells/mm3, and a prolonged bleeding time. The clotting time was normal. What is the most likely diagnosis?
- Which of the following statements is true about Trichomonas vaginalis?
- A lady from West Rajasthan presented with an ulcer surrounded by erythema on the right leg. Microscopy of the biopsy from the edge of the ulcer showed organisms with dark staining nuclei and kinetoplast. What is the most likely causative agent?
- A child presents with a fever and a rash. Urine examination showed cells with owl's eye appearance. What is the most likely diagnosis?
- Infection with Clonorchis sinensis is associated with an increased risk of__?
View More Questions