Question:
Which hormone is elevated in Addison's disease, leading to hyperpigmentation?
Which hormone is elevated in Addison's disease, leading to hyperpigmentation?
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Primary adrenal insufficiency causes high ACTH and hyperpigmentation.
Updated On: May 14, 2026
- Cortisol
- ACTH
- Aldosterone
- Renin
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The Correct Option is B
Solution and Explanation
Concept:
Addison's disease is primary adrenal insufficiency. Low cortisol causes increased ACTH due to loss of negative feedback. ACTH shares a precursor with melanocyte-stimulating hormone, causing hyperpigmentation.
Step 1: Understand primary adrenal insufficiency.
In Addison's disease, the adrenal cortex cannot produce enough cortisol.
Step 2: Effect on pituitary.
Low cortisol causes increased pituitary secretion of: \[ ACTH \]
Step 3: Cause of hyperpigmentation.
High ACTH is derived from POMC, which is related to melanocyte-stimulating activity. This causes: \[ \text{Hyperpigmentation} \]
Step 1: Understand primary adrenal insufficiency.
In Addison's disease, the adrenal cortex cannot produce enough cortisol.
Step 2: Effect on pituitary.
Low cortisol causes increased pituitary secretion of: \[ ACTH \]
Step 3: Cause of hyperpigmentation.
High ACTH is derived from POMC, which is related to melanocyte-stimulating activity. This causes: \[ \text{Hyperpigmentation} \]
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